Across TCGA pan-cancer cohorts, LINC02414 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of LINC02414’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where LINC02414 RNA is repressed in tumor relative to normal tissue. In most cancer types LINC02414 is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.
COAD and THCA are the cancer types where LINC02414 tumor–normal differential expression is most reproducible.