Across TCGA pan-cancer cohorts, LINC02386 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of LINC02386’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where LINC02386 RNA is repressed in tumor relative to normal tissue. In most cancer types LINC02386 is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.
KIRC are the cancer types where LINC02386 tumor–normal differential expression is most reproducible.