Across TCGA pan-cancer cohorts, LINC02376 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of LINC02376’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where LINC02376 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LINC02376 is over-expressed in tumor.
HNSC and THCA are the cancer types where LINC02376 tumor–normal differential expression is most reproducible.