Across TCGA pan-cancer cohorts, LINC02300 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of LINC02300’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where LINC02300 RNA is repressed in tumor relative to normal tissue. In most cancer types LINC02300 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.
BRCA and LUAD are the cancer types where LINC02300 tumor–normal differential expression is most reproducible.