Across TCGA pan-cancer cohorts, LINC02276 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of LINC02276’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where LINC02276 RNA is repressed in tumor relative to normal tissue. In most cancer types LINC02276 is over-expressed in tumor, although a few such as THCA and KIRP show the opposite, repressed pattern.
THCA and KIRP are the cancer types where LINC02276 tumor–normal differential expression is most reproducible.