LINC02259

Across TCGA pan-cancer cohorts, LINC02259 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of LINC02259’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where LINC02259 RNA is repressed in tumor relative to normal tissue. In most cancer types LINC02259 is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

KICH, KIRP, and THCA are the cancer types where LINC02259 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LINC02259 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	III,IV	−0.560	<.001	10	view →
KIRP	All	All	−0.159	<.001	8	view →
THCA	Male	All	−0.428	<.001	6	view →
KIRC	Male	All	−0.121	<.001	6	view →
CHOL	All	All	−0.464	<.001	3	view →
UCEC	All	IV	+0.240	.040	2	view →
COAD	Male	II,III,IV	+0.161	.032	2	view →
BLCA	All	All	+0.125	.019	2	view →
STAD	All	III,IV	+0.206	.017	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

LINC02259–KICH

Open the KICH breakdown →