LINC02228

Across TCGA pan-cancer cohorts, LINC02228 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of LINC02228’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where LINC02228 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LINC02228 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

HNSC, LIHC, and KIRC are the cancer types where LINC02228 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LINC02228 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.115	.001	8	view →
LIHC	All	All	+0.297	.001	4	view →
KIRC	All	All	−0.083	.013	4	view →
COAD	All	IV	+0.139	.043	2	view →
LUSC	Female	All	+0.216	.025	1	view →
THCA	Male	All	−0.135	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

LINC02228–HNSC

Open the HNSC breakdown →