Across TCGA pan-cancer cohorts, LINC02174 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of LINC02174’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where LINC02174 RNA is repressed in tumor relative to normal tissue. In most cancer types LINC02174 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.
KIRC and KIRP are the cancer types where LINC02174 tumor–normal differential expression is most reproducible.