Across TCGA pan-cancer cohorts, LINC02143 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of LINC02143’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where LINC02143 RNA is repressed in tumor relative to normal tissue. In most cancer types LINC02143 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.
KIRC and KIRP are the cancer types where LINC02143 tumor–normal differential expression is most reproducible.