Across TCGA pan-cancer cohorts, LINC02049 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of LINC02049’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where LINC02049 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LINC02049 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
LUSC and THCA are the cancer types where LINC02049 tumor–normal differential expression is most reproducible.