Across TCGA pan-cancer cohorts, LINC02023 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of LINC02023’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where LINC02023 RNA is repressed in tumor relative to normal tissue. In most cancer types LINC02023 is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.
COAD, HNSC, and READ are the cancer types where LINC02023 tumor–normal differential expression is most reproducible.