Across TCGA pan-cancer cohorts, LINC02016 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of LINC02016’s most consistent transcriptional readouts.
The strongest signal is observed in lung adenocarcinoma (LUAD), where LINC02016 RNA is repressed in tumor relative to normal tissue. In most cancer types LINC02016 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.
LUAD, LUSC, and BRCA are the cancer types where LINC02016 tumor–normal differential expression is most reproducible.