LINC01977

Across TCGA pan-cancer cohorts, LINC01977 RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of LINC01977’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where LINC01977 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LINC01977 is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.

THCA, KIRC, and COAD are the cancer types where LINC01977 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LINC01977 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	+1.550	<.001	11	view →
KIRC	Male	II,III,IV	−0.145	<.001	11	view →
COAD	Male	III,IV	+1.203	<.001	10	view →
LUAD	Male	II,III,IV	+1.220	<.001	9	view →
BLCA	All	All	+0.883	<.001	9	view →
READ	All	All	+0.665	<.001	7	view →
LIHC	All	All	+0.240	<.001	7	view →
UCEC	All	II,III,IV	+1.211	<.001	6	view →
BRCA	All	III,IV	+1.129	<.001	6	view →
LUSC	Male	II,III,IV	+0.805	<.001	6	view →
STAD	All	All	+0.361	.001	6	view →
CHOL	All	All	+1.448	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

LINC01977–THCA

Open the THCA breakdown →