Across TCGA pan-cancer cohorts, LINC01899 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of LINC01899’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where LINC01899 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LINC01899 is over-expressed in tumor, although a few such as THCA and LIHC show the opposite, repressed pattern.
KIRC, THCA, and LUSC are the cancer types where LINC01899 tumor–normal differential expression is most reproducible.