Across TCGA pan-cancer cohorts, LINC01880 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of LINC01880’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where LINC01880 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LINC01880 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.
KIRC, KIRP, and BRCA are the cancer types where LINC01880 tumor–normal differential expression is most reproducible.