Across TCGA pan-cancer cohorts, LINC01859 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of LINC01859’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where LINC01859 RNA is repressed in tumor relative to normal tissue. In most cancer types LINC01859 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.
BRCA are the cancer types where LINC01859 tumor–normal differential expression is most reproducible.