Across TCGA pan-cancer cohorts, LINC01858 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of LINC01858’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where LINC01858 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LINC01858 is over-expressed in tumor, although a few such as KIRP show the opposite, repressed pattern.
THCA, UCEC, and LUAD are the cancer types where LINC01858 tumor–normal differential expression is most reproducible.