Across TCGA pan-cancer cohorts, LINC01729 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of LINC01729’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where LINC01729 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LINC01729 is over-expressed in tumor, although a few such as PAAD and LUSC show the opposite, repressed pattern.
KIRC, PAAD, and HNSC are the cancer types where LINC01729 tumor–normal differential expression is most reproducible.