Across TCGA pan-cancer cohorts, LINC01689 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of LINC01689’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where LINC01689 RNA is repressed in tumor relative to normal tissue. In most cancer types LINC01689 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
THCA are the cancer types where LINC01689 tumor–normal differential expression is most reproducible.