Across TCGA pan-cancer cohorts, LINC01667 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of LINC01667’s most consistent transcriptional readouts.
The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where LINC01667 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LINC01667 is over-expressed in tumor, although a few such as BRCA and LUSC show the opposite, repressed pattern.
LIHC, UCEC, and BRCA are the cancer types where LINC01667 tumor–normal differential expression is most reproducible.