LINC01646

Across TCGA pan-cancer cohorts, LINC01646 RNA is linked to patient survival in 12 of 34 cancer types, making it the most broadly survival-associated LINC01646 data layer.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher LINC01646 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated LINC01646 expression acts as an unfavorable survival marker, although some lineages such as BLCA and ESCA show a favorable association.

CESC, THCA, and LUSC are the cancer types where LINC01646 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Tertile	All	0.399	0.750	<.001	144	view →
THCA	OS	Tertile	All	0.787	0.954	<.001	135	view →
LUSC	OS	Tertile	II,III,IV	0.043	0.781	<.001	54	view →
KIRC	DFS	Tertile	IV	0.214	0.518	.012	48	view →
SKCM	OS	Tertile	II,III,IV	0.513	0.766	<.001	45	view →
HNSC	DFS	Tertile	III,IV	0.247	0.629	.001	36	view →
BLCA	OS	Tertile	All	1.000	0.356	.030	18	view →
ESCA	DFS	Quartile	III,IV	0.614	0.262	.005	18	view →
LGG	DFS	Tertile	All	0.614	0.836	.001	12	view →
GBM	DFS	Tertile	All	0.031	0.243	<.001	9	view →
PCPG	DFS	Tertile	All	0.535	0.936	<.001	9	view →
UVM	DFS	Tertile	III,IV	0.321	0.747	.038	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

LINC01646–CESC (DFS)

Open the CESC breakdown →