Across TCGA pan-cancer cohorts, LINC01640 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of LINC01640’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where LINC01640 RNA is repressed in tumor relative to normal tissue. In most cancer types LINC01640 is over-expressed in tumor, although a few such as BRCA and ESCA show the opposite, repressed pattern.
BRCA, ESCA, and LUSC are the cancer types where LINC01640 tumor–normal differential expression is most reproducible.