Across TCGA pan-cancer cohorts, LINC01584 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of LINC01584’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where LINC01584 RNA is repressed in tumor relative to normal tissue. In most cancer types LINC01584 is over-expressed in tumor, although a few such as LUSC show the opposite, repressed pattern.
LUSC are the cancer types where LINC01584 tumor–normal differential expression is most reproducible.