Across TCGA pan-cancer cohorts, LINC01525 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of LINC01525’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where LINC01525 RNA is repressed in tumor relative to normal tissue. In most cancer types LINC01525 is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.
KIRC are the cancer types where LINC01525 tumor–normal differential expression is most reproducible.