Across TCGA pan-cancer cohorts, LINC01500 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of LINC01500’s most consistent transcriptional readouts.
The strongest signal is observed in lung adenocarcinoma (LUAD), where LINC01500 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LINC01500 is over-expressed in tumor, although a few such as BLCA show the opposite, repressed pattern.
LUAD, BRCA, and ESCA are the cancer types where LINC01500 tumor–normal differential expression is most reproducible.