Across TCGA pan-cancer cohorts, LINC01486 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of LINC01486’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where LINC01486 RNA is repressed in tumor relative to normal tissue. In most cancer types LINC01486 is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.
COAD are the cancer types where LINC01486 tumor–normal differential expression is most reproducible.