Across TCGA pan-cancer cohorts, LINC01441 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of LINC01441’s most consistent transcriptional readouts.
The strongest signal is observed in lung adenocarcinoma (LUAD), where LINC01441 RNA is repressed in tumor relative to normal tissue. In most cancer types LINC01441 is over-expressed in tumor, although a few such as LUAD and KIRP show the opposite, repressed pattern.
LUAD and KIRP are the cancer types where LINC01441 tumor–normal differential expression is most reproducible.