LINC01395

Across TCGA pan-cancer cohorts, LINC01395 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of LINC01395’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where LINC01395 RNA is repressed in tumor relative to normal tissue. In most cancer types LINC01395 is over-expressed in tumor, although a few such as HNSC and BRCA show the opposite, repressed pattern.

HNSC, LUAD, and LUSC are the cancer types where LINC01395 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LINC01395 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	−1.862	<.001	12	view →
LUAD	All	III,IV	+0.706	<.001	9	view →
LUSC	Male	All	+0.257	<.001	6	view →
LIHC	All	All	+0.042	.001	5	view →
BRCA	All	IV	−0.445	.028	4	view →
KIRP	Male	All	−0.140	.003	3	view →
KIRC	Female	IV	−0.139	.005	3	view →
BLCA	Male	All	+0.314	.049	2	view →
PRAD	All	All	−0.093	.031	2	view →
KICH	All	All	+0.271	.021	1	view →
THCA	All	II,III,IV	−0.052	.012	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

LINC01395–HNSC

Open the HNSC breakdown →