LINC01366

Across TCGA pan-cancer cohorts, LINC01366 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of LINC01366’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where LINC01366 RNA is repressed in tumor relative to normal tissue. In most cancer types LINC01366 is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

LUSC, LUAD, and BRCA are the cancer types where LINC01366 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LINC01366 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Male	III,IV	−1.009	<.001	8	view →
LUAD	Female	III,IV	−0.721	<.001	7	view →
BRCA	All	II,III,IV	−0.609	<.001	6	view →
UCEC	All	All	−0.293	<.001	6	view →
THCA	All	All	+0.261	<.001	6	view →
KIRC	Male	All	+0.222	<.001	6	view →
KICH	All	All	−0.331	.005	4	view →
CHOL	All	All	+0.266	.003	2	view →
PRAD	All	All	−0.099	.011	2	view →
LIHC	Female	All	+0.084	.042	2	view →
READ	Female	All	−0.205	.008	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

LINC01366–LUSC

Open the LUSC breakdown →