LINC01250

Across TCGA pan-cancer cohorts, LINC01250 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of LINC01250’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where LINC01250 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LINC01250 is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

HNSC, LUSC, and PAAD are the cancer types where LINC01250 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LINC01250 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.087	.001	8	view →
LUSC	All	All	+0.117	.001	4	view →
PAAD	Male	All	+0.055	.008	2	view →
COAD	All	II,III,IV	+0.029	.012	2	view →
KICH	Female	All	−0.020	.004	2	view →
CHOL	Female	All	+0.050	.007	1	view →
KIRP	Male	All	−0.018	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

LINC01250–HNSC

Open the HNSC breakdown →