LINC01249

Across TCGA pan-cancer cohorts, LINC01249 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of LINC01249’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where LINC01249 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LINC01249 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.

HNSC, BRCA, and LUSC are the cancer types where LINC01249 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LINC01249 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.481	.001	8	view →
BRCA	All	III,IV	−0.336	<.001	6	view →
LUSC	All	All	+0.796	<.001	5	view →
UCEC	All	All	+0.027	.032	2	view →
LUAD	All	All	+0.227	.012	1	view →
LIHC	All	All	+0.073	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

LINC01249–HNSC

Open the HNSC breakdown →