Across TCGA pan-cancer cohorts, LINC01231 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of LINC01231’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where LINC01231 RNA is repressed in tumor relative to normal tissue. In most cancer types LINC01231 is over-expressed in tumor, although a few such as BRCA and HNSC show the opposite, repressed pattern.
BRCA and HNSC are the cancer types where LINC01231 tumor–normal differential expression is most reproducible.