Across TCGA pan-cancer cohorts, LINC01218 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of LINC01218’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where LINC01218 RNA is repressed in tumor relative to normal tissue. In most cancer types LINC01218 is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.
COAD, LUAD, and READ are the cancer types where LINC01218 tumor–normal differential expression is most reproducible.