Across TCGA pan-cancer cohorts, LINC01189 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of LINC01189’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where LINC01189 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LINC01189 is over-expressed in tumor, although a few such as PRAD and ESCA show the opposite, repressed pattern.
KIRC, PRAD, and ESCA are the cancer types where LINC01189 tumor–normal differential expression is most reproducible.