Across TCGA pan-cancer cohorts, LINC01180 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of LINC01180’s most consistent transcriptional readouts.
The strongest signal is observed in lung adenocarcinoma (LUAD), where LINC01180 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LINC01180 is over-expressed in tumor, although a few such as PAAD show the opposite, repressed pattern.
LUAD and PAAD are the cancer types where LINC01180 tumor–normal differential expression is most reproducible.