Across TCGA pan-cancer cohorts, LINC01148 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of LINC01148’s most consistent transcriptional readouts.
The strongest signal is observed in esophageal carcinoma (ESCA), where LINC01148 RNA is repressed in tumor relative to normal tissue. In most cancer types LINC01148 is over-expressed in tumor, although a few such as ESCA show the opposite, repressed pattern.
ESCA and LIHC are the cancer types where LINC01148 tumor–normal differential expression is most reproducible.