LINC01127

Across TCGA pan-cancer cohorts, LINC01127 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of LINC01127’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where LINC01127 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LINC01127 is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

HNSC, KICH, and BRCA are the cancer types where LINC01127 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LINC01127 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.759	<.001	8	view →
KICH	Male	All	−1.804	<.001	7	view →
BRCA	All	III,IV	−0.228	<.001	6	view →
CHOL	Male	All	−2.158	<.001	4	view →
KIRC	All	All	+0.978	<.001	4	view →
LUSC	Male	All	+0.974	.001	3	view →
LIHC	All	II,III,IV	−0.581	.011	2	view →
ESCA	All	All	+0.563	.004	2	view →
KIRP	All	All	−0.532	.020	2	view →
READ	All	III,IV	+0.390	.038	2	view →
PRAD	All	All	−0.089	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

LINC01127–HNSC

Open the HNSC breakdown →