Across TCGA pan-cancer cohorts, LINC01109 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of LINC01109’s most consistent transcriptional readouts.
The strongest signal is observed in kidney chromophobe (KICH), where LINC01109 RNA is repressed in tumor relative to normal tissue. In most cancer types LINC01109 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.
KICH are the cancer types where LINC01109 tumor–normal differential expression is most reproducible.