Across TCGA pan-cancer cohorts, LINC01072 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of LINC01072’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where LINC01072 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LINC01072 is over-expressed in tumor, although a few such as HNSC show the opposite, repressed pattern.
LUSC, BRCA, and HNSC are the cancer types where LINC01072 tumor–normal differential expression is most reproducible.