LINC00997

Across TCGA pan-cancer cohorts, LINC00997 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of LINC00997’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where LINC00997 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LINC00997 is over-expressed in tumor, although a few such as BRCA and UCEC show the opposite, repressed pattern.

KIRC, HNSC, and LIHC are the cancer types where LINC00997 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LINC00997 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+0.767	<.001	12	view →
HNSC	Female	All	+0.776	<.001	11	view →
LIHC	Male	All	+0.737	<.001	9	view →
KIRP	All	II,III,IV	+0.898	<.001	8	view →
STAD	All	II,III,IV	+0.623	.010	4	view →
BRCA	Female	All	−0.315	<.001	4	view →
CHOL	Female	All	+1.780	<.001	3	view →
UCEC	All	All	−0.634	<.001	2	view →
PRAD	All	All	−0.247	<.001	2	view →
COAD	All	II,III,IV	+0.284	.045	1	view →
LUSC	All	All	−0.201	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

LINC00997–KIRC

Open the KIRC breakdown →