LINC00989

Across TCGA pan-cancer cohorts, LINC00989 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of LINC00989’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where LINC00989 RNA is repressed in tumor relative to normal tissue. In most cancer types LINC00989 is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

KICH, KIRC, and KIRP are the cancer types where LINC00989 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LINC00989 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	All	−0.670	<.001	10	view →
KIRC	Female	All	+0.702	<.001	9	view →
KIRP	Male	All	−0.553	<.001	9	view →
LUSC	All	II,III,IV	−0.180	<.001	7	view →
UCEC	All	All	−0.660	<.001	6	view →
BRCA	All	II,III,IV	−0.576	<.001	6	view →
LIHC	All	II,III,IV	+0.078	<.001	5	view →
LUAD	All	All	−0.089	.006	4	view →
BLCA	All	All	−0.237	.011	3	view →
PAAD	All	All	−0.207	.010	2	view →
PRAD	All	All	−0.179	<.001	2	view →
THCA	All	IV	−0.572	.013	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

LINC00989–KICH

Open the KICH breakdown →