Across TCGA pan-cancer cohorts, LINC00906 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of LINC00906’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where LINC00906 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LINC00906 is over-expressed in tumor, although a few such as BRCA and LUSC show the opposite, repressed pattern.
KIRC, BRCA, and LUSC are the cancer types where LINC00906 tumor–normal differential expression is most reproducible.