Across TCGA pan-cancer cohorts, LINC00845 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of LINC00845’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where LINC00845 RNA is repressed in tumor relative to normal tissue. In most cancer types LINC00845 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.
KIRC, KIRP, and KICH are the cancer types where LINC00845 tumor–normal differential expression is most reproducible.