LINC00640

Across TCGA pan-cancer cohorts, LINC00640 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of LINC00640’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where LINC00640 RNA is repressed in tumor relative to normal tissue. In most cancer types LINC00640 is over-expressed in tumor, although a few such as COAD and BRCA show the opposite, repressed pattern.

COAD, LUSC, and BRCA are the cancer types where LINC00640 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LINC00640 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	−0.175	<.001	10	view →
LUSC	All	II,III,IV	+1.091	<.001	6	view →
BRCA	All	III,IV	−1.073	<.001	6	view →
THCA	Male	All	−0.091	.001	4	view →
HNSC	Female	All	+0.613	.016	3	view →
BLCA	Male	All	+0.524	.048	2	view →
CHOL	All	All	+0.199	.001	2	view →
PRAD	All	All	−0.157	<.001	2	view →
LUAD	All	II,III,IV	−0.125	.007	2	view →
LIHC	Male	All	+0.050	.001	2	view →
KIRC	Male	III,IV	+0.033	.032	2	view →
READ	All	All	−0.185	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

LINC00640–COAD

Open the COAD breakdown →