Across TCGA pan-cancer cohorts, LINC00555 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of LINC00555’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where LINC00555 RNA is repressed in tumor relative to normal tissue. In most cancer types LINC00555 is over-expressed in tumor, although a few such as KIRC and COAD show the opposite, repressed pattern.
KIRC, COAD, and THCA are the cancer types where LINC00555 tumor–normal differential expression is most reproducible.