LINC00519

Across TCGA pan-cancer cohorts, LINC00519 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of LINC00519’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where LINC00519 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LINC00519 is over-expressed in tumor, although a few such as UCEC and BRCA show the opposite, repressed pattern.

HNSC, KIRC, and LUAD are the cancer types where LINC00519 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LINC00519 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	II,III,IV	+2.272	<.001	12	view →
KIRC	Male	IV	+0.504	<.001	11	view →
LUAD	Female	II,III,IV	+1.033	<.001	9	view →
LUSC	Female	II,III,IV	+3.718	<.001	7	view →
LIHC	All	All	+0.185	<.001	7	view →
UCEC	All	All	−0.693	.001	6	view →
BRCA	Female	II,III,IV	−0.300	.001	4	view →
CHOL	Male	All	+0.708	<.001	3	view →
KIRP	All	III,IV	+0.325	.004	3	view →
BLCA	All	All	+0.937	.038	2	view →
PRAD	All	All	−0.397	<.001	2	view →
KICH	Female	All	−0.251	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

LINC00519–HNSC

Open the HNSC breakdown →