Across TCGA pan-cancer cohorts, LINC00475 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of LINC00475’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where LINC00475 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LINC00475 is over-expressed in tumor, although a few such as UCEC and PRAD show the opposite, repressed pattern.
KIRC, THCA, and KIRP are the cancer types where LINC00475 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LINC00475 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.