LINC00458

Across TCGA pan-cancer cohorts, LINC00458 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of LINC00458’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where LINC00458 RNA is repressed in tumor relative to normal tissue. In most cancer types LINC00458 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH and KIRC are the cancer types where LINC00458 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LINC00458 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	All	−0.010	.021	1	view →
KIRC	Male	All	−0.004	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

LINC00458–KICH

Open the KICH breakdown →