Across TCGA pan-cancer cohorts, LINC00457 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of LINC00457’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where LINC00457 RNA is repressed in tumor relative to normal tissue. In most cancer types LINC00457 is over-expressed in tumor, although a few such as KIRC and LUSC show the opposite, repressed pattern.

KIRC, THCA, and LUSC are the cancer types where LINC00457 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LINC00457 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	−0.041	<.001	7	view →
THCA	Female	All	+0.310	<.001	6	view →
LUSC	Male	All	−0.096	<.001	4	view →
ESCA	All	All	−0.343	.002	2	view →
KIRP	Male	All	−0.055	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: LINC00457 RNA expression & survival · all LINC00457 data types