long intergenic non-protein coding RNA 456Genealiases: []
Q-omics provides the consensus-scored LINC00456 profile across patient tissues and cancer cell-line models. LINC00456 expression is associated with patient survival in 13 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, LINC00456 is differentially expressed in 2, with the highest sampling consensus in BLCA. Additionally, LINC00456 RNA expression shows 13,217 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight UVM, BLCA, and THYM as cancer lineages where LINC00456 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for LINC00456 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes LINC00456 survival associations across molecular data types. LINC00456 RNA expression shows survival associations in the most cancer types (13). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible LINC00456 RNA expression–survival associations across cancer types. High LINC00456 expression shows unfavorable associations in TGCT, CESC, LUSC, READ and KICH, but favorable associations in UVM. The UVM Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .003). Together, the overview and detailed table identify UVM as the clearest survival context for LINC00456 RNA expression.
This table summarizes LINC00456 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 2. The strongest signals are observed in BLCA for RNA.
This table ranks reproducible tumor–normal expression differences for LINC00456. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. LINC00456 shows higher tumor expression in BLCA and STAD. The BLCA box plot shows higher LINC00456 RNA expression in tumor versus normal tissue (log2 FC = +0.431, t-test p = .017).
This table shows molecular features associated with LINC00456 in patient tissues and cancer cell lines. In patient samples, LINC00456 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set.
